Dubai Chamber of Commerce and Industry was established in 1965 by a decree issued by the late Ruler of Dubai, Sheikh Rashid bin Saeed Al Maktoum, who realised the important role that a chamber of commerce could play in supporting the national economy. Thereby, Dubai Chamber started its activities with 450 members and a 12-member board of directors. The number of members increased to reach more than 140,000 by the end of 2012, representing all economic sectors.

With the number of members gradually increasing, Dubai Chamber opened two branches and four representative offices in different parts of Dubai, reaching out to members with its outstanding services no matter where the members were based. As well as its headquarters, the other branchis located in Jebel Ali Free Zone Authority (JAFZA. The four representative offices are located in Dubai Airport Free Zone (DAFZA), the Land Transport Customs Building in Al Aweer, Jebel Ali Free Zone, and Al Twar Centre.