Mafraq Hospital is situated 35 kilometers southeast of the UAE's capital, Abu Dhabi. Mafraq is an Arabic word meaning ‘meeting of roads' which is an apt description of the hospital's unique location at the intersection of major roadways.

The hospital was built, and opened, in 1983 as the largest tertiary referral treatment hospital in the United Arab Emirates at the time. Mafraq Hospital remains a tertiary hospital with 451 beds and services include medicine, obstetrics, pediatrics, as well as surgical and critical care services that support the trauma program. Mafraq Hospital operates the largest burn unit in the country and is a Center of Excellence for ENT and Thoracic surgery. The hospital also operates two primary healthcare clinics at Bani Yas and Al Nahda.

Mafraq Hospital is part of the SEHA HealthSystem and is owned and operated by Abu Dhabi Health Services Company PJSC (SEHA) which is responsible for the curative activities of the public hospitals and clinics of the Emirate of Abu Dhabi.